https://unasp.emnuvens.com.br/LifestyleJournal <p><strong>This journal is published in continuous publication model. This journal also adopts advanced publication in Early Access.</strong></p> <p>In order to disseminate works accepted for publication earlier than the standard production and issue release cycles, in January 2022<strong> Lifestyle </strong> <strong>Journal </strong>has implemented an “Early Access” option. Articles accepted for publication, yet scheduled for release in a forthcoming issue, will be displayed on a specific “Early Access” page so the articles can be read and cited before their scheduled release in a specific issue.</p> <p>The papers published as Early Access are final full-text, peer-reviewed, copyedited articles made available to the audience as soon as they are complete, published online before being assigned to a volume and issue of the journal. Early Access articles are considered fully complete, and once posted online are considered to be fully published and no further changes can be made by the authors. If there is an error in a paper published as Early Access, it would need to be corrected with an erratum. Early Access articles are fully citable since they are given a DOI, which allows them to be cited and tracked. After the article is assigned to an issue, the DOI remains the same and can continue to be used to cite the article.</p> Instituto Adventista de Ensino pt-BR Life style 2237-3756 https://unasp.emnuvens.com.br/LifestyleJournal/article/view/1873 <p><strong>Objective:</strong> To evaluate possible associations between weight loss and changes in hepatic transaminases in obese patients treated with a very low-calorie diet, comparing possible differences associated to sex and age group.</p> <p><strong>Method:</strong> This retrospective cohort analyzed medical records of 777 patients with severe obesity (grades II or III) treated with a 500–800 kcal/day diet between 2016 and 2022. Bioimpedance and laboratory tests were evaluated after 3 months of in-hospital intervention. The sample included individuals over 12 years old, totaling 1,142 hospitalized patients.</p> <p><strong>Results:</strong> The comparison between admission and discharge measurements revealed significant changes in body composition and in the GGT and ALT concentrations of the study participants. The reduction in body weight and fat mass in obese patients on a very low-calorie diet was directly and weakly associated with a reduction in liver transaminases, suggesting an improvement in liver function.</p> <p><strong>Conclusions:</strong> Hospital treatment for severe obesity was effective in promoting improvements in anthropometric measures after three months. The very low-calorie diet and lifestyle changes also provided evidence of improved liver function in patients, highlighting the importance of holistic management with multidisciplinary supervision.</p> Ana Dayrine Nunes da Silva Sérgio Q. Braga Domingos L. S. Rios Marcia Almeida Copyright (c) 2025 Life style 2025-01-01 2025-01-01 13 00 e1873 e1873 10.19141/2237-3756.lifestyle.v13.n00.pe1873